Deslorelin Acetate

Deslorelin Acetate Sequence: GLP-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-NHEt

Deslorelin Acetate CAS No.: 57773-65-6

Deslorelin Acetate Molecular Formula: C64H83N17O12

Deslorelin Acetate Molecular Weight: 1282.47

Deslorelin Acetate Purity (HPLC): 99.0%min.

Deslorelin Acetate Appearance: White powder

Deslorelin Acetate Single Impurity (HPLC): 0.5%max

Deslorelin Acetate Amino Acid Composition: ± 10% of theoretical

Deslorelin Acetate Peptide Content (N%): ≥ 80.0%

Deslorelin Acetate Water Content (Karl Fischer): ≤ 8.0%

Deslorelin Acetate Acetate Content (HPIC): ≤ 12.0%

Deslorelin Acetate MS (ESI): Consistent

Deslorelin Acetate Mass Balance: 95.0~105.0%

Deslorelin Acetate Grade: Pharmaceutical Grade

Deslorelin Acetate Storage: Closed, below 2 ~ 8º C preservation

Deslorelin Acetate Usage: Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin Acetate Description:

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).

Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin Acetate Application:

Deslorelin was successfully trialed in the US and was approved for veterinary use under certain circumstances. In Europe, it was approved for use in equine assisted reproduction.

It is also being trialed in humans to study its efficacy in treatment of breast cancer in women, and in treating precocious puberty and congenital adrenal hyperplasia in male and female children.